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Article

N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells.

Oncogene - 29 May 2008

Ushmorov A, Hogarty M D, Liu X, Knauss H, Debatin K M, Beltinger C

Abstract excerpt

N-myc has proapoptotic functions, yet it acts as an oncogene in neuroblastoma. Thus, antiapoptotic mechanisms have to be operative in neuroblastoma cells that antagonize the proapoptotic effects of N-myc. We conditionally activated N-myc in SH-EP neuroblastoma cells subjected to the trophic stress of serum or nutrient deprivation while changing the expression of Bcl-2, survivin and FLIP(L), antiapoptotic...

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Identifiers

PMID: 18193081
DOI: 10.1038/sj.onc.1211017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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