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Article

Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.

PloS one - 1 Jan 2012

Veschi Veronica, Petroni Marialaura, Cardinali Beatrice, Dominici Carlo, Screpanti Isabella, Frati Luigi, Bartolazzi Armando, Gulino Alberto, Giannini Giuseppe

Abstract excerpt

MYCN amplification occurs in about 20-25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes neuroblastoma cells to apoptosis, understanding the molecular mechanisms of which might be relevant for the therapy of MYCN amplified neuroblastoma. We recently...

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Source

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Identifiers

PMID: 23152863
DOI: 10.1371/journal.pone.0049139
PMCID: PMC3494673

Genes

MYCN
HIPK2
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Galectin-3 impairment of MYCN-dependent apoptosis-sensitive phenotype is antagonized by nutlin-3 in neuroblastoma cells.PMID 23152863Read ↗

MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63.Semantic proximity Read ↗

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.Semantic proximity Read ↗

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy CombinationSemantic proximity Read ↗

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastomaSemantic proximity Read ↗

Small-Molecule MDM2 Antagonists as a New Therapy Concept for NeuroblastomaSemantic proximity Read ↗

Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in NeuroblastomaSemantic proximity Read ↗

Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosisSemantic proximity Read ↗

Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction.Semantic proximity Read ↗

Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse modelsSemantic proximity Read ↗

The <i>MYCN</i> Enigma: Significance of <i>MYCN</i> Expression in NeuroblastomaSemantic proximity Read ↗

Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplificationSemantic proximity Read ↗

Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastomaSemantic proximity Read ↗

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