Article
A pro-inflammatory genotype predisposes to Barrett's esophagus.
Carcinogenesis - 1 May 2008
Moons L M G, Kusters J G, van Delft J H M, Kuipers E J, Gottschalk R, Geldof H, Bode W A, Stoof J, van Vliet A H M, Ketelslegers H B, Kleinjans J C S, Siersema P D
Abstract excerpt
INTRODUCTION: Severity of mucosal inflammation is shown to be associated with Barrett's esophagus (BE) development in animals. It has therefore been postulated that a strong pro-inflammatory host response predisposes to BE. AIM: To determine the impact of cytokine gene polymorphisms on the development of BE. METHODS: The multiplex SNaPshot method was used to determine interleukin (IL)-12B (A+1188C), IL-10...
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