IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

doi:10.1186/1465-9921-9-2

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Article

IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

Respiratory research - 10 Jan 2008

Sadeghnejad Alireza, Karmaus Wilfried, Arshad S Hasan, Kurukulaaratchy Ramesh, Huebner Marianne, Ewart Susan

Abstract excerpt

BACKGROUND: Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. METHODS: In the Isle of Wight birth cohort (UK, 1989-1999), five IL13 single nucleotide polymorphisms (SNPs): rs1800925 (-1112C/T),...

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PMID: 18186920
DOI: 10.1186/1465-9921-9-2
PMCID: PMC2265286

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