Article
Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes.
Clinical pharmacology and therapeutics - 1 Jul 2008
Wen M-S, Lee Mtm, Chen J-J, Chuang H-P, Lu L-S, Chen C-H, Lee T-H, Kuo C-T, Sun F-M, Chang Y-J, Kuan P-L, Chen Y-F, Charng M-J, Ray C-Y, Wu J-Y, Chen Y-T
Abstract excerpt
Polymorphisms in CYP2C9 and VKORC1 have been shown to be associated with warfarin dose requirements and could be used to predict warfarin dose. We conducted a prospective study in which warfarin dose was prescribed based on CYP2C9 and VKORC1 polymorphisms in 108 Han-Chinese patients without prior warfarin treatments. Using the genotype-based dosing, 83% of patients reached stable, therapeutic international...
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