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Article

Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer.

Cells - 16 Dec 2021

Farnsworth Dylan A, Chen Yankuan T, de Rappard Yuswack Georgia, Lockwood William W

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutations are the molecular driver of a subset of non-small cell lung cancers (NSCLC); tumors that harbor these mutations are often dependent on sustained oncogene signaling for survival, a concept known as "oncogene addiction". Inhibiting EGFR with tyrosine kinase inhibitors has improved clinical outcomes for patients; however, successive generations of inhibitors have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34944063
DOI: 10.3390/cells10123553
PMCID: PMC8699920

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