Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness.

doi:10.1007/s00335-007-9082-9

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Article

Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2008

Pinto Lawrence H, Eaton Emily, Chen Bohao, Fleisher Jonah, Shuster Dmitry, McCauley Joel, Kedainis Dalius, Siepka Sandra M, Shimomura Kazuhiro, Song Eun-Joo, Husain Aliya, Lakser Oren J, Mitchell Richard W, Dowell Maria L, Brown Melanie, Camoretti-Mercado Blanca, Naclerio Robert, Sperling Anne I, Levin Stephen I, Turek Fred W, Solway Julian

Abstract excerpt

We mutagenized male BTBR mice with N-ethyl-N-nitrosourea and screened 1315 of their G3 offspring for airway hyperresponsiveness. A phenovariant G3 mouse with exaggerated methacholine bronchoconstrictor response was identified and his progeny bred in a nonspecific-pathogen-free (SPF) facility where sentinels tested positive for minute virus of mice and mouse parvovirus and where softwood bedding was used. The...

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PMID: 18167028
DOI: 10.1007/s00335-007-9082-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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