Article
Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells.
The Journal of biological chemistry - 10 Sept 2004
Kaneko Mika, Kato Yukinari, Kunita Akiko, Fujita Naoya, Tsuruo Takashi, Osawa Motoki
Abstract excerpt
Aggrus, also called T1alpha and podoplanin, is a novel platelet aggregation-inducing factor that is expressed in various carcinoma cells. Aggrus/T1alpha/podoplanin is known to be expressed in lung type I alveolar cells or lymphatic endothelial cells. However, its physiological role has not been clarified. To assess the attribution of glycosylation to Aggrus platelet aggregation activity, recombinant molecules...
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