Article
Pbx3 is required for normal locomotion and dorsal horn development.
Developmental biology - 1 Feb 2008
Rottkamp Catherine A, Lobur Katherine J, Wladyka Cynthia L, Lucky Amy K, O'Gorman Stephen
Abstract excerpt
The transcription cofactor Pbx3 is critical for the function of hindbrain circuits controlling respiration in mammals, but the perinatal lethality caused by constitutively null mutations has hampered investigation of other roles it may play in neural development and function. Here we report that the conditional loss of Pbx3 function in most tissues caudal to the hindbrain resulted in progressive deficits of...
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