Clastogenic effects induced in vitro by CCNU and AMD during G2-phase in bone marrow cells of Wistar rats.

Article

Clastogenic effects induced in vitro by CCNU and AMD during G2-phase in bone marrow cells of Wistar rats.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie - 1 Jan 2000

Georgian L

Abstract excerpt

Three concentrations of CCNU and AMD (1, 5 and 10 micrograms/ml) were given to bone marrow cells of Wistar rats immediately after their removal from the body into the culture medium. Abnormal metaphases observed 2, 3 and 4 h later were considered to represent the effect induced by the two drugs o...

Topics

Animals
Bone Marrow Cells
DNA Replication
Dactinomycin
Dose-Response Relationship, Drug
G2 Phase
In Vitro Techniques
Lomustine
Mutation
Rats
Rats, Inbred Strains

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