Article
The effect of tetrahydrofuran on biological systems: does a hepatotoxic potential exist?
Drug and chemical toxicology - 1 Jan 1991
Moody D E
Abstract excerpt
Tetrahydrofuran (THF) is a widely used solvent in industry and research. THF is a weak toxin, with approximate acute LD50s in the range of 2 to 3 g/kg, 8 to 20 mg/L, and 800 mg/kg following oral, inhalation, and i.v. routes, respectively. The two primary signs of intoxication are narcosis and hep...
Topics
- Administration, Inhalation
- Administration, Oral
- Animals
- Female
- Furans
- Lethal Dose 50
- Liver
- Male
- Mixed Function Oxygenases
- Mutagenicity Tests
- Mutation
- Solvents