Article
The effect of tetrahydrofuran on biological systems: does a hepatotoxic potential exist?
Drug and chemical toxicology - 1 Jan 1991
Moody D E
Abstract excerpt
Tetrahydrofuran (THF) is a widely used solvent in industry and research. THF is a weak toxin, with approximate acute LD50s in the range of 2 to 3 g/kg, 8 to 20 mg/L, and 800 mg/kg following oral, inhalation, and i.v. routes, respectively. The two primary signs of intoxication are narcosis and hepatocellular dysfunction, both occurring at doses of approximately one-half of the lethal dose. Little is known...
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