Article
Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition.
Molecular oncology - 1 Jun 2013
Young Natalie R, Liu Jing, Pierce Carolyn, Wei Tai-Fen, Grushko Tatyana, Olopade Olufunmilayo I, Liu Wanqing, Shen Christine, Seiwert Tanguy Y, Cohen Ezra E W
Abstract excerpt
Despite nearly universal expression of the wild-type epidermal growth factor receptor (EGFR) and reproducible activity of EGFR inhibitors in patients with squamous cell carcinoma of the head and neck (SCCHN), the majority of patients will not have objective responses. The mechanisms of this intri...
Topics
- Animals
- Antineoplastic Agents
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Class I Phosphatidylinositol 3-Kinases
- Drug Resistance, Neoplasm
- ErbB Receptors
- Female
- Gefitinib
- Head and Neck Neoplasms
- Humans
- Mice
- Mice, Nude
- Mutation