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Article

Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy.

Free radical biology & medicine - 15 Jul 2005

Golden Tamara R, Hubbard Alan, Morten Karl J, Hinerfeld Doug, Melov Simon

Abstract excerpt

The majority of cellular superoxide is generated in the mitochondria as a by-product of normal oxidative metabolism. In the mitochondria, superoxide is detoxified by manganese superoxide dismutase (SOD2). Mice lacking SOD2 demonstrate a multifaceted neonatal lethal phenotype, including a spongiform encephalopathy that is preventable through antioxidant treatment. The molecular events behind the observed pathology...

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Identifiers

PMID: 15964507
DOI: 10.1016/j.freeradbiomed.2005.03.002

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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