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Article

An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation.

RNA (New York, N.Y.) - 1 Feb 2008

Harding Heather P, Lackey Jeremy G, Hsu Hao-Chi, Zhang Yuhong, Deng Jing, Xu Rui-Ming, Damha Masad J, Ron David

Abstract excerpt

Unconventional mRNA splicing by an endoplasmic reticulum stress-inducible endoribonuclease, IRE1, is conserved in all known eukaryotes. It controls the expression of a transcription factor, Hac1p/XBP-1, that regulates gene expression in the unfolded protein response. In yeast, the RNA fragments generated by Ire1p are ligated by tRNA ligase (Trl1p) in a process that leaves a 2'-PO4(2-) at the splice junction,...

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Identifiers

PMID: 18094117
DOI: 10.1261/rna.859908
PMCID: PMC2212252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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