Article
Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2008
Tesse Riccardina, Cardinale Fabio, Santostasi Teresa, Polizzi Angela, Mappa Luigi, Manca Antonio, De Robertis Francesco, Silecchia Ombretta, Armenio Lucio
Abstract excerpt
We genotyped three polymorphisms of the promoter region of the interleukin-10 (IL-10) gene in 220 CF patients from the CF Center of Bari, and tested for an association between genetic variants of the cytokine and chronic airway colonization with Pseudomonas aeruginosa. We found that carriers of the high-IL-10-producing-GCC haplotype had significantly higher risk of chronic pulmonary infection with the pathogen.
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