Calcium dependent conformational changes in human transglutaminase 2 and its implications in celiac disease.

doi:10.1016/j.jmgm.2026.109498

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Article

Calcium dependent conformational changes in human transglutaminase 2 and its implications in celiac disease.

Journal of molecular graphics & modelling - 1 Nov 2026

Srikanth Srimari, Karthikeyan Pavinap Priyaa, Sezen Mezya, Sridhar Dharineesh K, Doppalapudi Karthikeya, Sen Taner Z, Ulaganathan Venkatasubramanian, Yennamalli Ragothaman M

Abstract excerpt

Transglutaminase 2 (TG2) serves as a modifiable transamidating acyltransferase that precipitates calcium-induced protein alterations. The enzyme plays a crucial role in the cell and disease states, such as tissue repair, calcium signal transduction, celiac disease, and cancer. It is implicated in protein crosslinking and has been found in high concentrations in the small intestines of those with celiac disease....

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Topics

Transglutaminases
GTP-Binding Proteins
Humans
Protein Glutamine gamma Glutamyltransferase 2
Celiac Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Molecular Dynamics Simulation

Calcium

Polymorphism, Single Nucleotide

Protein Conformation

Catalytic Domain

Protein Binding

Binding Sites

Source

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Identifiers

PMID: 42520491
DOI: 10.1016/j.jmgm.2026.109498

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