Article
Equilibrium unfolding of the dimeric SAM domain of MAPKKK Ste11 from the budding yeast: role of the interfacial residues in structural stability and binding.
Biochemistry - 15 Jan 2008
Bhunia Anirban, Domadia Prerna N, Xu Xiaolong, Gingras Richard, Ni Feng, Bhattacharjya Surajit
Abstract excerpt
The sterile alpha motifs or SAM domains are small ( approximately 70 amino acids) protein-protein interaction modules that are involved in diverse functions ranging from cell signaling, transcription regulation, and scaffolding. The Ste11 protein kinase in the mitogen-activated protein kinase (MAPK) signaling cascades of the budding yeast is regulated by a SAM domain located at the N-terminus of the full-length...
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