Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer.

Cancer research - 15 Dec 2007

Strati Katerina, Lambert Paul F

Abstract excerpt

Infection with high-risk human papillomaviruses (HPV) and in particular the expression of the viral proteins E6 and E7 have been associated with the etiology of a subset of head and neck squamous cell cancer (HNSCC). However, the individual consequences of E6 and E7 expression in an in vivo model have not been examined in these tissues. We have used transgenes that direct expression of the HPV16 E6 and E7...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to Genes, Viral
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogenes

Share to Papillomaviridae

Share to Phenotype

Share to Retinoblastoma Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18089787
DOI: 10.1158/0008-5472.CAN-07-3007
PMCID: PMC2859176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer.PMID 18089787Read ↗

Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.Semantic proximity Read ↗

Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse modelSemantic proximity Read ↗

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo.Semantic proximity Read ↗

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiationSemantic proximity Read ↗

Pocket Proteins Suppress Head and Neck CancerSemantic proximity Read ↗

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogeneSemantic proximity Read ↗

Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in miceSemantic proximity Read ↗

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In VivoSemantic proximity Read ↗

Papillomavirus E6 and E7 proteins and their cellular targetsSemantic proximity Read ↗

Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression ProfilingSemantic proximity Read ↗

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.Semantic proximity Read ↗

Identification of Head and Neck Cancer Subtypes Based on Human Papillomavirus Presence and E2F-Regulated Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.