Article
Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.
Cancer research - 1 Oct 2006
Balsitis Scott, Dick Fred, Dyson Nicholas, Lambert Paul F
Abstract excerpt
High-risk human papillomaviruses (HPV) encode two oncogenes, E6 and E7, expressed in nearly all cervical cancers. In vivo, HPV-16 E7 has been shown to induce multiple phenotypes in the context of transgenic mice, including cervical cancer. E7 is a multifunctional protein known best for its abilit...
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