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Article

Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.

Cancer research - 1 Oct 2006

Balsitis Scott, Dick Fred, Dyson Nicholas, Lambert Paul F

Abstract excerpt

High-risk human papillomaviruses (HPV) encode two oncogenes, E6 and E7, expressed in nearly all cervical cancers. In vivo, HPV-16 E7 has been shown to induce multiple phenotypes in the context of transgenic mice, including cervical cancer. E7 is a multifunctional protein known best for its ability to inactivate the tumor suppressor pRb. To determine the importance of pRb inactivation by E7 in cervical cancer, we...

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Source

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Identifiers

PMID: 17018593
DOI: 10.1158/0008-5472.CAN-06-0984
PMCID: PMC2858286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.PMID 17018593Read ↗

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