Article
Recent acceleration of human adaptive evolution.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2007
Hawks John, Wang Eric T, Cochran Gregory M, Harpending Henry C, Moyzis Robert K
Abstract excerpt
Genomic surveys in humans identify a large amount of recent positive selection. Using the 3.9-million HapMap SNP dataset, we found that selection has accelerated greatly during the last 40,000 years. We tested the null hypothesis that the observed age distribution of recent positively selected linkage blocks is consistent with a constant rate of adaptive substitution during human evolution. We show that a...
Topics
- Animals
- Biological Evolution
- Cluster Analysis
- Evolution, Molecular
- Gene Frequency
- Genetics, Population
- Genome, Human
- Heterozygote
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Models, Statistical
- Models, Theoretical
- Mutation