Article
In vitro capability of faropenem to select for resistant mutants of Streptococcus pneumoniae and Haemophilus influenzae.
Antimicrobial agents and chemotherapy - 1 Feb 2008
Kosowska-Shick Klaudia, Clark Catherine, Credito Kim, Dewasse Bonifacio, Beachel Linda, Ednie Lois, Appelbaum Peter C
Abstract excerpt
When tested against nine strains of pneumococci and six of Haemophilus influenzae of various resistotypes, faropenem failed to select for resistant mutants after 50 days of consecutive subculture in subinhibitory concentrations. Faropenem also yielded low rates of spontaneous mutations against all organisms of both species. By comparison, resistant clones were obtained with macrolides, ketolides, and quinolones.
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