Article
In vitro development of resistance to telithromycin (HMR 3647), four macrolides, clindamycin, and pristinamycin in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Feb 2000
Davies T A, Dewasse B E, Jacobs M R, Appelbaum P C
Abstract excerpt
The ability of 50 sequential subcultures in subinhibitory concentrations of telithromycin (HMR 3647), azithromycin, clarithromycin, erythromycin A, roxithromycin, clindamycin, and pristinamycin to select for resistance was studied in five macrolide-susceptible and six macrolide-resistant pneumococci containing mefE or ermB. Telithromycin selected for resistance less often than the other drugs.
Topics
- Anti-Bacterial Agents
- Clindamycin
- Drug Resistance, Microbial
- Genes, Bacterial
- Humans
- Ketolides
- Macrolides
- Microbial Sensitivity Tests
- Mutation
- Streptococcus pneumoniae
- Virginiamycin