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Article

In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 May 1999

Davies T A, Pankuch G A, Dewasse B E, Jacobs M R, Appelbaum P C

Abstract excerpt

The ability of 50 sequential subcultures in subinhibitory concentrations of ciprofloxacin, levofloxacin, grepafloxacin, sparfloxacin, trovafloxacin, and amoxicillin-clavulanate to select for resistance was studied for six penicillin-susceptible and four penicillin-intermediate pneumococci. Subculturing in ciprofloxacin, grepafloxacin, levofloxacin, and sparfloxacin led to selection of mutants requiring increased...

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Identifiers

PMID: 10223932
DOI: 10.1128/AAC.43.5.1177
PMCID: PMC89129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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