Article
In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 May 1999
Davies T A, Pankuch G A, Dewasse B E, Jacobs M R, Appelbaum P C
Abstract excerpt
The ability of 50 sequential subcultures in subinhibitory concentrations of ciprofloxacin, levofloxacin, grepafloxacin, sparfloxacin, trovafloxacin, and amoxicillin-clavulanate to select for resistance was studied for six penicillin-susceptible and four penicillin-intermediate pneumococci. Subculturing in ciprofloxacin, grepafloxacin, levofloxacin, and sparfloxacin led to selection of mutants requiring increased...
Topics
- Amoxicillin-Potassium Clavulanate Combination
- Anti-Infective Agents
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Genes, Bacterial
- Mutation
- Quinolones
- Streptococcus pneumoniae