Article
In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides.
The Journal of antimicrobial chemotherapy - 1 Oct 2005
Carsenti-Dellamonica H, Galimand M, Vandenbos F, Pradier C, Roger P M, Dunais B, Sabah M, Mancini G, Dellamonica P
Abstract excerpt
OBJECTIVES: To evaluate the rate of acquisition of resistance to linezolid and macrolides in Streptococcus pneumoniae isolates with different levels of susceptibility to penicillin and erythromycin. MATERIALS AND METHODS: Thirty strains of S. pneumoniae were tested by serial passages in subinhibitory concentrations of each antibiotic by the spiral method. The four copies of the 23S rRNA rrl gene of parent strains...
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