Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.

doi:10.1158/1055-9965.EPI-07-0494

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2007

Hung Rayjean J, Baragatti Meili, Thomas Duncan, McKay James, Szeszenia-Dabrowska Neonila, Zaridze David, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Foretova Lenka, Janout Vladimir, Bencko Vladimir, Chabrier Amelie, Moullan Norman, Canzian Federico, Hall Janet, Boffetta Paolo, Brennan Paul

Abstract excerpt

The DNA repair systems maintain the integrity of the human genome and cell cycle checkpoints are a critical component of the cellular response to DNA damage. We hypothesized that genetic variants in DNA repair and cell cycle control pathways will influence the predisposition to lung cancer, and studied 27 variants in 17 DNA repair enzymes and 10 variants in eight cell cycle control genes in 1,604 lung cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Checkpoint Kinase 2

Share to DNA Glycosylases

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Smoking

Share to Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 18086781
DOI: 10.1158/1055-9965.EPI-07-0494

Genes

CHEK2
MGMT
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.PMID 18086781Read ↗

Genetic variants in DNA repair pathways and risk of upper aerodigestive tract cancers: combined analysis of data from two genome-wide association studies in European populations.Semantic proximity Read ↗

International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.Semantic proximity Read ↗

Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair.Semantic proximity Read ↗

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.Semantic proximity Read ↗

Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer.Semantic proximity Read ↗

Heritable susceptibility factors for the development of cancer.Semantic proximity Read ↗

Characterization of functional excision repair cross-complementation group 1 variants and their association with lung cancer risk and prognosis.Semantic proximity Read ↗

The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.Semantic proximity Read ↗

XRCC1 632 as a candidate for cancer predisposition via a complex interaction with genetic variants of base excision repair and double strand break repair genes.Semantic proximity Read ↗

Association between the hOGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis based on 22,475 subjects.Semantic proximity Read ↗

Genetic variants in cell cycle control pathway confer susceptibility to lung cancer.Semantic proximity Read ↗

Sequence variants in cell cycle control pathway, X-ray exposure, and lung cancer risk: a multicenter case-control study in Central Europe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.