Article
Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells.
Biochemical and biophysical research communications - 29 Feb 2008
Warotayanont Rungnapa, Zhu Danhong, Snead Malcolm L, Zhou Yan
Abstract excerpt
Leucine-rich amelogenin peptide (LRAP), an alternatively spliced amelogenin protein, possesses a signaling property shown to induce osteogenic differentiation. In the current study, we detected LRAP expression during osteogenesis of wild-type (WT) embryonic stem (ES) cells and observed the absence of LRAP expression in amelogenin-null (KO) ES cells. We explored the signaling effect of LRAP on wild-type ES cells,...
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