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Article

Use of RUNX2 expression to identify osteogenic progenitor cells derived from human embryonic stem cells.

Stem cell reports - 10 Feb 2015

Zou Li, Kidwai Fahad K, Kopher Ross A, Motl Jason, Kellum Cory A, Westendorf Jennifer J, Kaufman Dan S

Abstract excerpt

We generated a RUNX2-yellow fluorescent protein (YFP) reporter system to study osteogenic development from human embryonic stem cells (hESCs). Our studies demonstrate the fidelity of YFP expression with expression of RUNX2 and other osteogenic genes in hESC-derived osteoprogenitor cells, as well as the osteogenic specificity of YFP signal. In vitro studies confirm that the hESC-derived YFP(+) cells have similar...

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Source

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Identifiers

PMID: 25680477
DOI: 10.1016/j.stemcr.2015.01.008
PMCID: PMC4325195

Genes

RUNX2
BMP2
FGF9

Provenance

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