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Article

A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer.

Breast cancer research and treatment - 1 Nov 2007

Jansson Agneta, Carlsson Jonas, Olsson Anette, Storm Petter, Margolin Sara, Gunnarsson Cecilia, Stenmark-Askmalm Marie, Lindblom Annika, Persson Bengt, Stål Olle

Abstract excerpt

In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the mechanism...

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Identifiers

PMID: 17260097
DOI: 10.1007/s10549-006-9477-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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