Article
The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis.
Human immunology - 1 Nov 2007
Begovich Ann B, Chang Monica, Caillier Stacy J, Lew David, Catanese Joseph J, Wang Joanne, Hauser Stephen L, Oksenberg Jorge R
Abstract excerpt
Recently published genetic studies in psoriasis, inflammatory bowel disease, and ankylosing spondylitis identified significant associations with IL12B and IL23R polymorphisms. An important role for the IL-12/IL-23 pathway in multiple sclerosis (MS) is supported by immunologic studies in patients...
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