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Article

Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma.

Journal of the National Cancer Institute - 4 Apr 2001

Guruswamy S, Lightfoot S, Gold M A, Hassan R, Berlin K D, Ivey R T, Benbrook D M

Abstract excerpt

BACKGROUND: Retinoic acid analogues, called retinoids, have shown promise in clinical trials in preventing breast and ovarian cancers. Classic retinoids bind to retinoic acid receptors, which regulate cell growth. Some novel retinoids, such as fenretinide, i.e., N-(4-hydroxyphenyl)retinamide (4-HPR), induce apoptosis through retinoic acid receptor-independent mechanisms; however, they appear to do so only at...

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Source

Identifiers

PMID: 11287445
DOI: 10.1093/jnci/93.7.516

Genes

MUC1
HPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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