Parental Influence on Intracerebral Hemorrhage Onset in Hereditary Dutch-Type Cerebral Amyloid Angiopathy.

doi:10.1159/000540040

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Article

Parental Influence on Intracerebral Hemorrhage Onset in Hereditary Dutch-Type Cerebral Amyloid Angiopathy.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2025

Rasing Ingeborg, Jellema Lisa, Voigt Sabine, Kaushik Kanishk, Koemans Emma A, van Zwet Erik W, van Etten Ellis S, Greenberg Steven M, van Walderveen Marianne A A, Terwindt Gisela M, Wermer Marieke J H

Abstract excerpt

INTRODUCTION: Dutch-type cerebral amyloid angiopathy (D-CAA) is an autosomal dominant hereditary form of CAA causing intracerebral hemorrhage (ICH) and cognitive decline. The age of onset of ICH in D-CAA mutation carriers is strikingly variable and ranges from late thirties up to 70 years. We investigated the presence of genetic anticipation and assessed the influence of parental age at onset and sex on age of...

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Topics

Humans
Female
Male
Age of Onset
Middle Aged
Cerebral Hemorrhage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Adult

Aged

Genetic Predisposition to Disease

Cerebral Amyloid Angiopathy, Familial

Mutation

Netherlands

Sex Factors

Heredity

Phenotype

Parents

Databases, Factual

Source

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Identifiers

PMID: 38952109
DOI: 10.1159/000540040
PMCID: PMC12324696

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