Article
Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2008
Cann Gordon M, Guignabert Christophe, Ying Lihua, Deshpande Niru, Bekker Janine M, Wang Lingli, Zhou Bin, Rabinovitch Marlene
Abstract excerpt
Murine light chain 3 (LC3) exists as two isoforms, LC3alpha and beta: LC3beta is an RNA-binding protein that enhances fibronectin (FN) mRNA translation, and is also a marker of autophagy. We report embryonic expression patterns for LC3alpha and LC3beta, with some overlap but notable differences in the brain, and in tissues of non-neuronal origin. LC3beta knockout (-/-) mice develop normally without a compensatory...
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