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Article

Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome.

Biochemical and biophysical research communications - 6 Jan 2006

Wu Jiaxue, Dang Yongjun, Su Wei, Liu Chao, Ma Haijie, Shan Yuxi, Pei Yuan, Wan Bo, Guo Jinhu, Yu Long

Abstract excerpt

Rat microtubule-associated protein light chain 3 (LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of rat LC3 is cleaved by a cysteine protease-Atg4, to produce LC3-I, which is located in cytosolic fraction. LC3-I can be converted to LC3-II through the processing by Atg7 (E1-like enzyme) and Atg3 (E2-like enzyme). LC3-II is modified by...

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PMID: 16300744
DOI: 10.1016/j.bbrc.2005.10.211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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