Two critical residues in p-loop regions of puffer fish Na+ channels on TTX sensitivity.

Abstract excerpt

We previously showed that Asn-383 and Thr-1569 residues of p-loop regions in domains I and IV, respectively, of the puffer fish, Fugu pardialis, skeletal muscle Na(v) (fNa(v)1.4a), are anomalous to those of other species of TTX-sensitive Na(+) channels, where the aromatic residues of Phe or Tyr, and Gly are the counterparts [Yotsu-Yamashita, M., Nishimori, K., Nitanai, Y., Isemura, M., Sugimoto, A., Yasumoto, T.,...

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