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Article

Comparative pharmacology and cloning of two novel arachnid sodium channels: Exploring the adaptive insensitivity of scorpion to its toxins.

FEBS letters - 7 Aug 2006

Zuo Xiao-Pan, He Hui-Qiong, He Ming, Liu Zhi-Rui, Xu Qing, Ye Jian-Guo, Ji Yong-Hua

Abstract excerpt

Scorpion toxins have been found lacking effect on Na(+) current of its own sodium channel, whereas the molecular mechanism remains mystery. In this study, the binding affinity of pharmacologically distinct scorpion toxins was found much weaker to scorpion (Buthus martensii) nerve synaptosomes than to spider (Ornithoctonus huwena) ones. The sodium channel cDNA from these two species were further cloned. The...

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Identifiers

PMID: 16870180
DOI: 10.1016/j.febslet.2006.07.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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