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Article

Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution

7 Dec 2007

Abstract excerpt

BACKGROUND: In vertebrates, tandem arrays of TTAGGG hexamers are present at both telomeres and intrachromosomal sites (interstitial telomeric sequences (ITSs)). We previously showed that, in primates, ITSs were inserted during the repair of DNA double-strand breaks and proposed that they could arise from either the capture of telomeric fragments or the action of telomerase. RESULTS: An extensive comparative...

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Share to Chromosomal and Genetic Variations
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PMID: 18067655
DOI: 10.1186/gb-2007-8-12-r260

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