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Article

Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin.

Oncogene - 8 May 2008

Maddika S, Wiechec E, Ande S R, Poon I K, Fischer U, Wesselborg S, Jans D A, Schulze-Osthoff K, Los M

Abstract excerpt

Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not harm the cells, indicating that nuclear localization of apoptin is insufficient for its...

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Identifiers

PMID: 18059340
DOI: 10.1038/sj.onc.1210958
PMCID: PMC2954967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin.PMID 18059340Read ↗

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