Article
Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS).
Disease markers - 1 Jan 2008
Abdollahi Mohammad Reza, Huang Shuwen, Rodriguez Santiago, Guthrie Philip Alexander Isles, Smith George Davey, Ebrahim Shah, Lawlor Debbie A, Day Ian N M, Gaunt Tom R
Abstract excerpt
Current literature suggests that ACE SNP rs4343, ACE 2350A>G in exon 17, T202T, may be the best proxy for the ACE Alu I/D whereas rs4363 and rs4362 may be slightly stronger predictors of ACE levels. Considering reported difficulties in genotyping ACE I/D and stronger associations of rs4343 than ACE I/D with plasma ACE levels in Africans, and suitability of rs4343 for allelic mRNA (cDNA) studies, we developed and...