Article
ACE I/D gene variant predicts ACE enzyme content in blood but not the ACE, UCP2, and UCP3 protein content in human skeletal muscle in the Gene SMART study.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Sept 2018
Yan Xu, Dvir Noam, Jacques Macsue, Cavalcante Luiz, Papadimitriou Ioannis D, Munson Fiona, Kuang Jujiao, Garnham Andrew, Landen Shanie, Li Jia, O'Keefe Lannie, Tirosh Oren, Bishop David J, Voisin Sarah, Eynon Nir
Abstract excerpt
Angiotensin-converting enzyme (ACE) is expressed in human skeletal muscle. The ACE I/D polymorphism has been associated with athletic performance in some studies. Studies have suggested that the ACE I/D gene variant is associated with ACE enzyme content in serum, and there is an interaction between ACE and uncoupling proteins 2 and 3 (UCP2 and UCP3). However, no studies have explored the effect of ACE I/D on ACE,...
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