Article
CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer.
Cancer research - 1 Dec 2007
Zhang Zhengyan, Borecki Ingrid, Nguyen Loan, Ma Duanduan, Smith Kimberly, Huettner Phyllis C, Mutch David G, Herzog Thomas J, Gibb Randall K, Powell Matthew A, Grigsby Perry W, Massad L Stewart, Hernandez Enrique, Judson Patricia L, Swisher Elizabeth M, Crowder Sara, Li Jianduan, Gerhard Daniela S, Rader Janet S
Abstract excerpt
We previously mapped a nonrandom frequent loss of heterozygosity (LOH) region in cervical cancers to 1 Mb of 6p23. Here, we describe the identification of a novel cervical cancer susceptibility gene, CD83. The gene was identified by several complementary approaches, including a family-based association study, comparison of transcript expression in normal and cancerous tissue, and genomic sequencing of candidate....
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