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Article

Structural determinants of substrate access to the disulfide oxidase Erv2p.

Journal of molecular biology - 9 Dec 2005

Vala Andrea, Sevier Carolyn S, Kaiser Chris A

Abstract excerpt

Erv2p is a small, dimeric FAD-dependent sulfhydryl oxidase that generates disulfide bonds in the lumen of the endoplasmic reticulum. Mutagenic and structural studies suggest that Erv2p uses an internal thiol-transfer relay between the FAD-proximal active site cysteine pair (Cys121-Cys124) and a second cysteine pair (Cys176-Cys178) located in a flexible, substrate-accessible C-terminal tail of the adjacent dimer...

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Source

Identifiers

PMID: 16288914
DOI: 10.1016/j.jmb.2005.09.076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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