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Article

Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells.

Development (Cambridge, England) - 1 Jan 2008

Su You-Qiang, Sugiura Koji, Wigglesworth Karen, O'Brien Marilyn J, Affourtit Jason P, Pangas Stephanie A, Matzuk Martin M, Eppig John J

Abstract excerpt

Oocyte-derived bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are key regulators of follicular development. Here we show that these factors control cumulus cell metabolism, particularly glycolysis and cholesterol biosynthesis before the preovulatory surge of luteinizing hormone. Transcripts encoding enzymes for cholesterol biosynthesis were downregulated in both Bmp15(-/-) and...

Read the complete abstract on PubMed

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Share to Bone Morphogenetic Protein 15
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Knockout

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Source

Identifiers

PMID: 18045843
DOI: 10.1242/dev.009068

Genes

BMP15
GDF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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