Culture independent analysis of ileal mucosa reveals a selective increase in invasive <i>Escherichia coli</i> of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum

Abstract excerpt

Intestinal bacteria are implicated increasingly as a pivotal factor in the development of Crohn's disease, but the specific components of the complex polymicrobial enteric environment driving the inflammatory response are unresolved. This study addresses the role of the ileal mucosa-associated microflora in Crohn's disease. A combination of culture-independent analysis of bacterial diversity (16S rDNA library...

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