Article
PTB/hnRNP I is required for RNP remodeling during RNA localization in Xenopus oocytes.
Molecular and cellular biology - 1 Jan 2008
Lewis Raymond A, Gagnon James A, Mowry Kimberly L
Abstract excerpt
Transport of specific mRNAs to defined regions within the cell cytoplasm is a fundamental mechanism for regulating cell and developmental polarity. In the Xenopus oocyte, Vg1 RNA is transported to the vegetal cytoplasm, where localized expression of the encoded protein is critical for embryonic polarity. The Vg1 localization pathway is directed by interactions between key motifs within Vg1 RNA and protein factors...
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