Article
DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity.
BMC medical genetics - 6 Feb 2008
Fan Bao Jian, Pasquale Louis, Grosskreutz Cynthia L, Rhee Douglas, Chen Teresa, DeAngelis Margaret M, Kim Ivana, del Bono Elizabeth, Miller Joan W, Li Tiansen, Haines Jonathan L, Wiggs Janey L
Abstract excerpt
BACKGROUND: Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with broad ethnic diversity, we show that three common SNPs in LOXL1 previously associated with pseudoexfoliation in Nordic populations are significantly associated with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. METHODS: Three LOXL1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.