Article
Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis.
Journal of neuroimmunology - 1 Jan 2008
Sakthivel Priya, Ramanujam Ryan, Wang Xiong Biao, Pirskanen Ritva, Lefvert Ann Kari
Abstract excerpt
The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-surface protein level, there were significant elevated levels of PD-1 on T cells and its ligand...
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