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Article

Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis.

Scientific reports - 14 Dec 2021

Wang Tianfeng, Xu Si, Zhang Huixue, Lu Xiaoyu, Li Shuang, Liu Li, Kong Xiaotong, Gao Hongyu, Wang Xu, Ning Shangwei, Wang Jianjian, Wang Lihua

Abstract excerpt

Myasthenia gravis (MG) is a complex neurological autoimmune disease with a pathogenetic mechanism that has yet to be elucidated. Emerging evidence has revealed that genes, non-coding RNAs and genetic variants play significant roles in the pathogenesis of MG. However, the molecular mechanisms of single nucleotide polymorphisms (SNPs) located on lncRNAs could disturb lncRNA-mediated ceRNA regulatory functions still...

Topics

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Biomarkers, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Myasthenia Gravis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

RNA, Long Noncoding

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Identifiers

PMID: 34907261
DOI: 10.1038/s41598-021-03357-x
PMCID: PMC8671434

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