Article
Different susceptibility of human immunodeficiency virus type 1 to Env gp41-derived synthetic peptides corresponding to the C-terminal heptad repeat region.
Microbes and infection - 1 Mar 2005
N A Panasda Isarangkura, Li Gui-Mei, Warachit Jiranan, Iwabu Yukie, Tsuji Shoutaro, Auwanit Wattana, Yamamoto Daisuke, Goto Toshiyuki, Hayashi Yoshio, Kiso Yoshiaki, Ikuta Kazuyoshi
Abstract excerpt
Two functional domains, alpha-helical heptad repeat 1 (HR-1) and HR-2, located in the N-terminal and C-terminal regions of human immunodeficiency virus type 1 (HIV-1) Env gp41, respectively, play an important role in the fusion process. Synthetic 34-amino-acid peptide that contains the HR-2 region, named C34, has been shown to inhibit the HIV-1 fusion process. Here, we prepared six representative peptides...
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