Article
HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview.
Molecules (Basel, Switzerland) - 15 Dec 2014
Férir Geoffrey, Gordts Stephanie C, Schols Dominique
Abstract excerpt
The glycoproteins on the surfaces of enveloped viruses, such as HIV, can be considered as a unique target for antiviral therapy. Different carbohydrate-binding agents (CBAs) target specific glycans present on viral glycoproteins of enveloped viruses. It has been shown that long-term CBA pressure in vitro can result in mutant HIV-1 isolates with several N-linked glycan deletions on gp120. These studies...
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