Article
Evaluating candidate genes in common epilepsies and the nature of evidence.
Epilepsia - 1 Mar 2008
Pal Deb K, Strug Lisa J, Greenberg David A
Abstract excerpt
Very few genetic associations for idiopathic epilepsy have been replicated and this has tempered enthusiasm for the results of genetic studies in epilepsy. What are the reasons for lack of replication? While type 1 error, population stratification, and multiple testing have been discussed extensively, the importance of genetic heterogeneity has been relatively neglected. In the first part of this review, we...
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